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Female hormones have been playing a major role in a womans life. But, when they are fluctuated before menstruation; anxiety, depression, craving for foods, headache, fluid retention, abdominal bloating and breast tenderness could happen to 50% to 90% of women and it is known as Premenstrual Syndrome (PMS).

At some point in every woman's life, her hormone production drops below the level required to continue her periods and it is known as Menopause. Due to the decrease of the estrogen and progesterone, when menopause comes upon a woman, there is a big change in physiological and emotional conditions. Hot flash, sleep disturbance and night sweat, change in appearance and mood swing are always occurred on this stage of life. Cardiovascular disease, osteoporosis, stress urinary incontinence and weight gain are happened more often after menopause. To reduce theses symptoms, doctors used to prescribe Hormone Replacement Therapy (HRT) for post-menopause women. But, it has been found to cause severe adverse effect to the user. On the other hand, phytoestrogens have been proved to be as effective and much safer alternatives to HRT. Phytoestrogens also have the remarkable ability to increase estrogenic effects when estrogen levels are low, and decrease them when levels are too high.

EstroWell is formulated with natural phytoestrogens to ease the uncomfortable physical and mental symptoms that occur before the onset of the womans menstrual period and to support women during their change of life. From Isoflavone to herbs like Black Cohosh, Dong Qui, Wild Yam and Red Clover, all are the sources of natural plant estrogen and progesterone, plus St. Johns Wort, Evening Primrose to calm the emotional fluctuation in this period. Also, Astragalus and Siberian Ginseng are added to bring the total wellbeing to the female body.

Don Quai

In traditional Chinese medicine, Dong Quai (Angelica sinensis) is used primarily to "balance" the female system and thus ease menstrual irregularities and menopausal complaints. Modern herbalists also recommend it for anemia, fatigue, constipation, anxiety, and PMS.

Don Quai helps balance out hormone levels, reduces uterine cramps and helps minimize breast tenderness. Many believe Don Quai works by relaxing the muscles in the uterus. It may also help improve liver metabolism. Numerous Chinese case studies suggest that herbal formulas containing Dong Quai may be helpful with menstrual irregularities
Pueraria

Chemicals extracted from kudzu (Pueraria lobata) include the isoflavones- daidzein, daidzin, genistein, and puerarin. Isoflavones have been extensively studied for their phytoestrogenic properties. It is known that daidzein and genistein can bond to the estrogen receptors. There are reports for their benefits on cardiovascular health, bone density, cancer prevention and total wellbeing for the post menopause women.

The Journal of the American Medical Association (JAMA) says postmenopausal osteoporosis results largely from accelerated bone loss occurring in the years following menopause. For women, the most accelerated bone loss occurs the first five years after menopause. A recent study reported that ipriflavone prevented this rapid bone loss. The 56 women participants took either ipriflavone with 1000 mg of calcium or calcium alone. After two years, vertebral bone density had declined in women taking calcium alone but there was no bone loss in the group taking ipriflavone. (However, unlike soy which not only supports healthy bones but also curbs menopausal symptoms, ipriflavones estrogen-like properties end at the bone. It has no effect on reproductive tissue atrophy.) Am. J. Clinical Nutrition reported another study that stated the phytoestrogens, mainly daidzein and genistein, "are responsible for the bone sparing effects. Daidzein is similar in shape to a drug called Ipriflavone which is used throughout Europe and Asia to treat osteoporosis." In fact, the roots of kudzu contain some 25 times more daidzein than soybean does. (Kaufman et al., 1997)
Red Clover Menopause increases a woman's risk for developing cardiovascular disease. Supplementation with Red Clover (Trifolium pratense) isoflavones has been associated with a sizeable increase in high-density lipoprotein (HDL) cholesterol, or "good" cholesterol in pre- and postmenopausal women, leading some researchers to believe that these isoflavones may help protect against cardiovascular disease. Several studies suggest that it may significantly reduce hot flashes, slow bone loss and even boost bone mineral density in perimenopausal and post-menopause women.
Black Cohosh Black cohosh (Cimicifuga racemosa) is an herb which appears to affect estrogenic receptors. In Germany (where herbal remedies can be officially approved if they are known to be safe and if there is "reasonable certainty" of benefit), black cohosh root is officially approved to be sold for the reduction of PMS. Most of the scientific study of this herb, however, has focused on the treatment of menopausal symptoms rather than PMS. No controlled trials have demonstrated the efficacy of black cohosh in PMS. No serious toxicity has been reported for this herb. A study recently reported in Menopause: Journal of the North American Menopause Society. The findings reported that using black cohosh is a safe treatment for short-term relief of menopausal symptoms such as hot flashes, night sweats, irritability, and sleep disorders. Some studies have found it to cause an increase in vaginal epithelium that is superior to estrogen replacements. Unlike HRT, black cohosh is not associated with increased breast cancer rates, or dysfunctional uterine bleeding. It is not habit-forming. It does not toxic.

Recent papers have been heralding black cohosh for osteoporosis. The Journal of the Society of Obstetricians and Gynaecologists of Canada (Nov/Dec 1998) concluded that a black cohosh preparation, Remifemin, is a useful alternative for menopause in their compilation on menopause and osteoporosis.
St. Johns Wort

A pilot study using St. Johns Wort (Hypericum perforatum) standardized extract, 300 mg. three times daily, was recently investigated. After taking St. Johns Wort for two complete menstrual cycles, daily symptoms were rated. The degree of improvement in overall premenstrual syndrome scores was 51%, with over two-thirds of the women demonstrating at least a 50% decrease in symptom severity. Moods showed the most improvement (57%); and, the symptoms with the greatest reductions in scores were: crying (92%), depression (85%), confusion (75%), feeling out of control (72%), nervous tension (71%), anxiety (69%) and insomnia (69%). In Germany, extract of black cohosh is commonly combined with St John's Wort for the treatment of menopausal symptoms.
Wild Yam

Wild yam root (Dioscorea villosa) contains diosgenin, a substance used in the laboratory synthesis of steroid hormones. The use of this herb in the treatment of PMS is based on the rationale that diosgenin will be converted in the body into progesterone, which may relieve premenstrual symptoms.

Progesterone plays a profoundly more critical role in the maintenance of female health than previously assumed. Too little of this vital female hormone can lead to all kinds of menstrual disorders, infertility, miscarriages, osteoporosis and even cancer. Progesterone deficiencies are much more common that most of us would assume, even in younger women. The very delicate relationship between progesterone and estrogen levels is what creates hormonal balance. When a womans body experiences an imbalance of progesterone resulting in estrogen dominance, a variety of pre-menstrual symptoms can result.

Progesterone which is derived from wild yam is almost identical in its chemical structure to the natural progesterone synthesized by the human body. When wild yam is absorbed into the body it is easily converted into the same molecule, a process which does not occur with synthetic varieties. The transition is easy and natural.
Astragalus Astragalus (Astragalus membranaceous) is one of the important Chinese medicinal herbs which are widely used to boosts energy, increases stress adaptation. It has been used together with Dong Quai to stimulate red blood cell production and increase blood flow throughout the body.
Siberian Ginseng

Siberian Ginseng (Eleutherococcus senticosus) may positively affect hormone levels and tone the large uterine muscle. These properties make it potentially valuable for easing certain menstrual difficulties and menopausal symptoms.
Evening Primrose Oil

Evening Primrose oil (Oenothera biennis) is a biennial herb native to North America. Its seed oil is used medicinally and is considered on natural sources of the essential fatty acid (EFA) gamma linoleic acid (GLA). EPO is commonly used to treat PMS, eczema, diabetic neuropathy, fibrocystic breasts, cyclic mastalgia, and rheumatoid arthritis. British physicians routinely recommend EPO supplements for women suffering from cyclic mastalgia.

The rationale for the many different uses of EPO is based on the metabolism of GLA into various prostaglandins. EPO is thought to help in PMS by modulating endogenous inflammatory symptoms. Levels of GLA tend to be lower in women suffering from PMS, particularly mastalgia, than in women without PMS.

Prudent use of Essential Fatty Acids (EFAs) and their metabolites may reduce bone matrix collagen degradation while increasing bone mineral content. With increasing evidence that prostaglandins and prostaglandin inhibitors influence bone metabolism, it's nice to look at prostaglandin precursors in EPO.